Neuroblastoma Treatment and Clinical TrialsNeuroblastoma Treatment and Clinical Trials

Neuroblastoma Treatment and Clinical Trials

Loading share tools...

Neuroblastoma treatment advancements through clinical trials

Over the years, many research studies (also known as clinical trials) have been conducted to understand the best ways to treat neuroblastoma. From these clinical trials, oncologists have established current standards for neuroblastoma treatment. Find more information on the current neuroblastoma treatment options.

A series of key clinical trials over this period improved treatment for each type of neuroblastoma:

High-risk neuroblastoma survival rates improve with treatment advancements

← Swipe left to right to view results →

Event-free survival, or EFS, is the length of time after treatment during which your child has no changes in their disease, such as the disease coming back (relapse), onset of new symptoms, or death.

Even though progress has been made, oncologists and researchers continue to develop new clinical trials with the hope of improving outcomes. As a result, many children with neuroblastoma are invited to enroll in a clinical trial as a part of their therapy.

Here is some information that may help when you are considering a clinical trial for your child.

Introduction to clinical trials

Clinical trials are research studies that test new ways to improve treatments in a group of people with a certain disease. In neuroblastoma, clinical trials often focus on new treatments to see if they are safer or more effective than what is currently available.

Clinical trials are research studies that test new ways to improve treatments in a group of people with a certain disease

Clinical trials follow strict standards and are completely voluntary

  • Clinical trials follow strict rules set by the Food and Drug Administration (FDA). These rules make sure that clinical trials are as safe as possible
  • Participation in clinical trials is completely voluntary and you may choose to withdraw your child from a clinical trial at any time if you change your mind

Clinical trials are broken out by phases

Neuroblastoma clinical trials happen in phases. Goals for each trial depend on its phase and your child’s diagnosis.

The goal for a specific clinical trial will depend on the phase it's in.

  • Early phase trials (phase 1 or 2) generally test whether new treatments are safe and effective
    • Children with relapsed or refractory neuroblastoma are most commonly enrolled in phase 1 or 2 trials
  • Later phase trials (phase 3) generally test the standard treatment against a new alternative treatment. The goal for this type of trial is to see if the new alternative treatment helps to increase cure rates, decrease side effects, or limit late effects of treatment
    • Children newly diagnosed with neuroblastoma are most commonly enrolled in phase 3 trials
Clinical trials follow strict standards and are completely voluntary

Clinical trials may vary based on location

Different hospitals are associated with different research organizations, so some clinical trials may only be available at certain hospitals. Learn more about the different research groups in neuroblastoma.

Clinical trials may provide your child the opportunity to receive cutting-edge treatment. Children with neuroblastoma are living longer today because of past clinical trials that showed new treatments were safe and effective.

Find detailed information on the different phases of a clinical trial.

The decision to explore clinical trials or choose the current standard treatment is one that should be made along with your child’s oncologist. Because every neuroblastoma diagnosis is unique, your child’s oncologist can help you find the treatment best tailored to meet the needs of your child.